We only track statistical software that addresses the Design of Experiments market. For a very complete and up to date list of general statistical software, visit Rainer Wuerlaender's List. Please let us know if another big statistical company is turning its attention to DOE.
Aptech -- Creators of Gauss
Brooks Software -- Makers of Cornerstone and RS-1, statistical software with DOE modules.
MathSoft -- Makers of MathCad, Axum, S-Plus and other related software.
MathWorks -- Makers of MatLab
MiniTab -- Makers of MiniTab
SAS -- SAS now makes a tool called the ADX Interface to simplify design and analysis of experiments.
SPSS -- They have been around since before computers, at least since before computers that didn't require their own room.
StatGraphics -- from Statistical Graphics Corporation.
Statistica -- A general statistics program with some customization for DOE